New report now available: HCV Drugs and Vaccines Development Status – 201707 February 2017
Antiviral InteliStrat Inc. is preparing for scientists and decision makers a unique, exhaustive review of the HCV research and development field as it is in early 2017. See Table of Contents ("NEWS" Tab)
The Challenges of Poliovirus Eradication, by J.Yelle12 January 2017
Following the successful efforts to wipe out the virus of Smallpox (Variola virus) that started in the 1950s and officially realized their goal in 19803, the World Health Organization (WHO) made a commitment in 1988 to eradicate Poliovirus and poliomyelitis and achieve a Polio-free world by 2000. This ambitious project proved to be much more challenging than initially anticipated.
See complete publication in "NEWS" section (Tab)
The Urgent Need for Broad-Spectrum Antiviral Drugs, by J. Yelle18 March 2015
Database User Guide
- First-level, general information displayed in the form of a Table
- Detailed information on specific products in the form of Product files that can be accessed by clicking on a product’s name in the Table
- Sponsor(s): Main group involved in product development. Note that Product files can also mention co-sponsors and partners also playing a role in product development.
- Product: Product name and synonyms (italics)
- Type of product: Nature of the product, based on the following categories:
- Vaccine: product used to elicit immune response
- Immunomodulator: product that can modulate immune response
- Antibodies: immunoglobulins raised against a particular antigen
- Inhibitor: product interfering with viral or cellular process(es)
- Inhibitor & Immunomodulator: product harboring properties of inhibitor and immunomodulator
- Other: product acting through a mechanism distinct from the above
- Mode of action: Mechanism of action of products acting as inhibitors:
3A IN: inhibitor of Rhinovirus protein 3A a-gluco IN: alpha-glucosidase I inhibitor Antisense: RNA or DNA molecule which binds to complementary strand of nucleic acid (usually in a target mRNA) to inhibit gene expression cdk IN: inhibitor of cellular cyclin-dependent kinase Cyclophil IN: inhibitor of cellular cyclophilin DHS IN: inhibitor of cellular deoxyhypusine synthase DNA Pol IN: DNA polymerase inhibitor DOHH IN: inhibitor of cellular deoxyhypusine hydroxylase EI: entry inhibitor EI/MI: inhibitor of both viral entry and maturation process EI/Regul IN: inhibitor of both viral entry and viral regulatory protein Encaps IN: encapsidation inhibitor HDAC1 IN: inhibitor of cellular histone deacetylase I enzyme Hel IN: helicase inhibitor Hel-Pri IN: helicase-promase complex inhibitor HI-NA IN: inhibitor of hemagglutinin-neuraminidase enzyme II: integrase inhibitor II/EI: inhibitor of both integrase enzyme and entry process II/PIC: inhibitor of both integrase enzyme and pre-integration complex Ion IN: ion-channel forming protein (viroporin) inhibitor IRES IN: internal ribosome entry site inhibitor MI: maturation inhibitor Multiple: more than 2 concurrent inhibitory activities NA IN: neuraminidase inhibitor NcRTI: nucleoside-competing reverse transcriptase inhibitor NNRTI: non-nucleoside reverse transcriptase inhibitor NNRTI/EI: inhibitor acting both as NNRTI and entry inhibitor NRTI: nucleoside reverse transcriptase inhibitor NRTI/NNRTI: mixture of NRTI and NNRTI NS5A IN: inhibitor of non-structural NS5A phosphoprotein PARP IN: inhibitor of cellular poly-ADP ribose polymerase PI: protease inhibitor PIC IN: inhibitor of pre-integration complex PPRTI: pyrophosphate reverse transcriptase inhibitor Regul IN: inhibitor of viral regulatory protein Release IN: inhibitor of virion release from infected cells Ribozyme: “Ribonucleic acid enzyme”, RNA molecule catalyzing cleavage of target RNA sequences RNA Pol IN: RNA polymerase inhibitor RNAse: ribonuclease RT-like IN: inhibitor of reverse transcriptase-like enzyme RNAi: RNA interfering (including siRNA, shRNA, ddRNAi, etc) SVM: selective viral mutagenesis Uncoat IN: inhibitor of viral uncoating in entry process Unknown: mechanism of action not yet determined Unspecified: mechanism of action unspecified or undisclosed by sponsor Zn-f IN: zinc-finger inhibitor
- Mode of action: Types of vaccines:
Inactivated vaccine, whole or split virions:
Suspension of purified whole or split virions (including Influenza virus “subvirion” vaccines), chemically or physically inactivated to remove infectivity, used to elicit immune response
Live attenuated vaccine:
Suspension of live, attenuated virus with limited replication capacity or pathogenicity, including reassortant viruses from the same viral family, used to elicit immune response
Recombinant protein vaccine:
Purified viral proteins obtained using genetic recombination and expression vectors, used as protein suspension or added to liposomes, virosomes or VLPs to elicit immune response, with or without adjuvant
Non-recombinant protein vaccine:
Purified viral proteins obtained directly from virions or subvirion particles, and used as suspension or added to liposomes or virosomes to elicit immune response with or without adjuvant
Synthetic peptides derived from natural or modified amino acid sequence of viral proteins, used to elicit immune response with or without adjuvant
Recombinant vaccine, viral expr vector:
Viral expression vector or chimeric/recombinant viruses (usually from different viral families), used as vaccine to express viral antigens and elicit immune response
Recombinant vaccine, plasmid expr vector:
Plasmid expression vector used as vaccine to produce viral antigens and elicit immune response
Viral protein or peptide chemically bound to another molecule or recombinantly expressed as a fusion protein with exogenous amino acid sequences, used to elicit immune response
Related virus vaccine:
A distinct virus in the same viral family but with limited replication capacity or reduced pathogenicity is used to elicit immune response
- Viral Family: Name of viral family according to taxonomic criteria, ending with “viridae” (see Viral Taxonomy page for further information)
- Virus: Virus name. Sometimes, where a product is developed for more than one virus in a single viral family without further precision on the actual virus names, or when a products is developed for closely related viruses in the same viral family, a generic name such as “Herpesviruses” or “Poxviruses” can appear in the grid.
- Status-1: Current stage of development of the product, including:
- Research stage (basic science / discovery)
- Preclinical (assays and animal testing intended to support IND filing)
- IND filing
- Clinical stage: Phases I, I/II, II, II/III, III
- NDA/BLA filing
- Status-2: Additional information and details regarding product’s stage of development
When using the default "Page View" mode, click on the triangle-shaped cursors at the bottom of the pages (left and right corners) to go to the next pages. You can also select a specific page number by moving the cursor between the "<" and ">" symbols along the dotted line at the bottom of the page.
Alternatively, you can click on "Show or print as a continuous list" at the bottom of the page to see (and print) the Table as a continuous list. This option can also be used when conducting searches in the Database.
- Click here to view the Database User Guide
This leads to the Database User Guide that can be consulted at all time by subscribers.
- View all available products
This option allows the user to see all the products listed in the Database and some other information that depends on the type of subscription:
- Custom Access subscribers are allowed to see only the list of products and the viral family names. All the other columns of the Table appear as empty, except for some demo products which are free such as: ChimeriVax-Dengue, Retrovir, P-1946 and Focetria®. Subscribers can click on any product’s name to see a new window showing the cost of the corresponding file. To buy a Product file, they just click on the link “Click here to buy access”, which leads them to the payment site. After a Product file is bought, it becomes part of the list displayed when “View all the products I have access” is selected.
- Viral Family Access subscribers are allowed to see the list of products and the viral family names, along with the demo products. In addition, they see all the products that correspond to the viral family they have selected. For these products, they see the complete set of information in the Table’s columns and have access to their Product files by clicking on the product’s name in the Table. They can also click at any moment on a product’s name not included in their Viral Family package to see the cost of the corresponding file and decide if they buy it. To buy a Product file, they just click on the link “Click here to buy access”, which leads them to the payment site. After a Product file is bought, it becomes part of the list of products displayed when “View all the products I have access” is selected.
- Full Access subscribers are allowed to see the complete list of products (including the demo products) with all the information available in the Table’s columns and product files. They have illimited access to the information in the Database and have no need to buy any additional product files.
- View all the products I have access
This option allows the user to see only the products that have been bought, along with the demo products.
- Custom Access subscribers will see the demo products along with the product files they have bought, if any.
- Viral Family Access subscribers will see the demo products along with the products that correspond to the viral family they have selected and any other product files that have been bought, if any.
- Full Access subscribers will see the complete list of products (including the demo products) with all the information available in the Table’s columns and product files. For these subscribers, there is no difference between “View all available products” and “View all the products I have access”.
- Custom Access subscription, and Viral Family Access subscription:
SEARCH is essentially a basic search module, with the ability to perform searches using just one criterion: either Product name or Viral family name.
- Full Access subscription:
These subscribers can use the SEARCH module with additional search criteria not available to Custom Access and Viral Family Access subscribers. Also, they can use the ADVANCED SEARCH module which allows single or multiple criteria searches based on Sponsor name, Product name, Product type, Mode of action, Viral family, Virus, and development Status. All these criteria can be combined for highly targeted searches.