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A New Era in the Treatment of Chronic HCV Infection
08 June 2011In May 2011, the FDA has approved two new drugs to treat chronic hepatitis C (HCV) infection. The two drugs, Boceprevir (Victrelis) from Merck & Co. and Telaprevir (Incivek) from Vertex (in collaboration with Tibotec), both act as inhibitors of HCV's protease enzyme. This is the first time in...
New Treatments Available Soon for HCV Infection
03 May 2011On April 27 and 28, the FDA's Antiviral Drugs Advisory Committee reviewed all available data presented to support approval of two new molecules developed separately by Merck & Co. (initially by Schering-Plough) and Vertex Pharmaceuticals for the treatment of chronic HCV infection.
The two...
HIV can use ribonucleotides to replicate inside macrophages
01 February 2011In a paper published in Journal of Biological Chemistry (Dec. 10 issue), Kennedy et al. from University of Rochester Medical Center and Emory University reported evidence that HIV has developed an original strategy to replicate efficiently in non-dividing macrophages despite the absence of...
Conferences
Frontiers of Retrovirology 2011
Amsterdam, Netherlands (Mövenpick Hotel) October 3-5, 2011 www.frontiers-of-retrovirology.com
62nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
San Francisco (CA), USA - November 4-8, 2011 http://www.aasld.org/lm/Pages/TheLiverMeeting2011.aspx
The Fifth International Workshop on HIV Persistence during Therapy
St Martin, West Indies - December 6-9, 2011 http://www.hiv-workshop.com/
Simplified taxonomy of main viruses infecting humans
The diagram below displays a simplified classification scheme of the main viruses commonly associated with human diseases, based on International Committee on Taxonomy of Viruses Database (ICTVdB) and other sources.
Viral family names end with "viridae", sub-family with "virinae" and genus with "virus". Mononegavirales and Nidovirales represent two viral orders regrouping viral families.
In the diagram, viruses with single-stranded DNA genome are indicated as ss DNA and those with single-stranded RNA, as ss RNA. Viruses with double-stranded DNA genome are indicated as ds DNA and those with double-stranded RNA, as ds RNA.
Move your mouse on top of viral family names in the diagram to reveal names of the main human viruses that belong to these families. Some of the viruses listed are naturally found in animal species but can occasionally infect humans as well.
Use the diagram to facilitate your search in the database and identify viruses according to their taxonomic status.
- Reoviridae (ds RNA)
- Orthoreovirus: Mammalian orthoreovirus
Rotavirus: Human Rotavirus - Hepadnaviridae (DNA - RNA - DNA)
- Adenoviridae (ds DNA)
- Mastadenovirus: Human adenoviruses
- Poxviridae (ds DNA)
- Orthopoxvirus: Vaccinia virus; Variola virus
- Herpesviridae (ds DNA)
- Alphaherpesvirinae
Simplexvirus: Human herpesvirus 1, 2 (Herpes simplex, HSV-1, HSV-2)
Varicellovirus: Human herpesvirus 3 (Varicella-Zoster virus, VZV)
Betaherpesvirinae
Cytomegalovirus: Human herpesvirus 5 (Human cytomegalovirus, CMV)
Roseolovirus: Human herpesvirus 6, 7
Gammaherpesvirinae
Lymphocryptovirus: Human herpesvirus 4 (Epstein-Barr virus, EBV)
Rhadinovirus: Human herpesvirus 8 (Kaposis sarcoma-associated herpesvirus, KSHV) - Papillomaviridae (ds DNA)
- Alphapapillomavirus: Human papillomavirus 2, 6, 7, 10, 16, 18, 26, 32, 34, 53, 54, 61, 71, cand90
Betapapillomavirus: Human papillomavirus 5, 9, 49, cand92, cand96
Gammapapillomavirus: Human papillomavirus 4, 48, 50, 60, 88
Mupapillomavirus: Human papillomavirus 1, 63
Nupapillomavirus: Human papillomavirus 41 - Polymaviridae (ds DNA)
- Polyomavirus (SV40-like subgroup): BK polyomavirus (BKPyV); JC polyomavirus(JCPyV); KI polyomavirus (Karolinska Institutet virus, KIPyV); WU polyomavirus (Washington University virus, WUPyV)
Polyomavirus (Murine polyomavirus-like subgroup): Merkel cell polyomavirus (MCV or MCPyV) - Parvoviridae (ss DNA)
- Erythrovirus: Human parvovirus B19
Dependovirus: Human adeno-associated virus
Bocavirus: Human bocavirus (HBoV) - Hepatitis delta virus (HDV) (ss RNA (-) polarity)
- NOT ASSIGNED TO A FAMILY
- Rhabdoviridae (Mononegavirales) (ss RNA (-) polarity)
- Lyssavirus: Rabies virus
Vesiculovirus: Vesicular Stomatitis virus (VSV) - Filoviridae (Mononegavirales) (ss RNA (-) polarity)
- Marburgvirus: Lake Victoria Marburgvirus (Marburg virus)
Ebolavirus: Zaire virus (Ebola virus) - Paramyxoviridae (Mononegavirales) (ss RNA (-) polarity)
- Respirovirus: Human parainfluenzavirus 1, 3 (PIV)
Morbillivirus: Measles virus
Rubulavirus: Mumps virus Human parainfluenzavirus 2, 4 (PIV)
Henipavirus: Hendra virus; Nipah virus
Pneumovirus: Human respiratory syncytial virus (RSV)
Metapneumovirus: Human metapneumovirus (MPV) - Bunyaviridae (ss RNA (-) polarity)
- Orthobunyavirus: Bunyamwera virus; California Encephalitis virus
Hantavirus: Hantaan virus; Sin Nombre virus
Nairovirus: Crimean-Congo Haemorrhagic Fever virus (CCHFV)
Phlebovirus: Rift Valley Fever virus (RVFV); Punta Toro virus - Arenaviridae (ss RNA (-) polarity)
- Orthomyxoviridae (ss RNA (-) polarity)
- Influenzavirus A: Influenza A virus
Influenzavirus B: Influenza B virus
Influenzavirus C: Influenza C virus - Coronaviridae (Nidovirales) (ss RNA (+) polarity)
- Flaviviridae (ss RNA (+) polarity)
- Flavivirus: Yellow Fever virus (YFV); Tick-borne Encephalitis virus (TBEV); Dengue virus; Modoc virus; Japanese Encephalitis virus (JEV); St-Louis Encephalitis virus (SLEV); West Nile virus (WNV)
Hepacivirus: Hepatitis C virus (HCV); Hepatitis G virus (HGV, GB virus) - Togaviridae (ss RNA (+) polarity)
- Alphavirus: Sindbis virus; Eastern Equine Encephalitis virus (EEE); Semliki Forest virus; Venezuelan Equine Encephalitis virus (VEE); Western Equine Encephalitis virus (WEE); Chikungunya virus
Rubivirus: Rubella virus - Picornaviridae (ss RNA (+) polarity)
- Hepatitis E Virus (HEV) (ss RNA (+) polarity)
- NOT ASSIGNED TO A FAMILY
- Caliciviridae (ss RNA (+) polarity)
- Norovirus: Norwalk virus
Sapovirus: Sapporo virus - Astroviridae (ss RNA (+) polarity)
- Mamastroviridae: Human astrovirus 1 to 8
- Retroviridae (RNA - DNA - RNA)
- Deltaretrovirus: Human T-lymphotropic virus 1, 2 (HTLV-1, 2)
Gammaretrovirus: Xenotropic murine leukemia-related virus (XMRV)
Lentivirus: Human immunodeficiency virus 1, 2 (HIV-1, 2)